Click the title above to link to the new paper out of my lab at UCSF that was published today in Cell. The audio clip is an interview with my boss, Stavros Lomvardas, giving a brief introduction to this beautiful paper which details graduate student Josie Clowney’s work on profiling the nuclear architecture of olfactory sensory neurons.
- In olfactory neurons, OR genes converge in specialized heterochromatic foci
- The active OR allele in each neuron is transcribed outside of these foci
- Lamin B receptor (LBR) downregulation allows OR aggregation in olfactory neurons
- Ectopic LBR expression disrupts OR foci and causes OR coexpression